Page 28 - Hikma - Oncology booklet

Dosage adjustments recommendations

Dose modifications in Combination with Cisplatin and 5-fluorouraci
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episode 20%.
1 st  fluorouracil dose by

Diarrhea 2 nd episode Then  eutaxer injection

Grade 3 dose by 20%.

1 st episode  Eutaxer & fluorouracil
doses by 20%.

Diarrhea 2 nd episode Discontinue treatment.

Grade 4

Grade 2

 Cisplatin dose
by 20%. Grade 3
Peripheral Discontinue

Neuropathy
treatment.

ST
1 EPISODE 2 ND EPISODE 3 RD EPISODE

Stomatitis &  Fluorouracil Stop fluorouracil  Eutaxer dose

Mucositis dose by 20%. only by 20%
Grade 3

1 ST EPISODE 2 ND EPISODE

Stop fluorouracil  Eutaxer dose by
Stomatitis & only 20%
Mucositis

Grade 4
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