Page 27 - Hikma - Oncology booklet
P. 27
Dosage cont.
Induction therapy of locally advanced inoperable SCCHN
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Followed by cisplatin 75 mg/m IV
2
(Day 1) , followed by fluorouracil 750
75 2
mg/m 2 mg/m per day as a 24-hr IV infusion
(Days 1 to 5), starting at end of
cisplatin infusion; for 4 cycles.
Induction therapy for locally advanced (unresectable, low
surgical cure, or organ preservation) SCCHN:
2
Followed by cisplatin 100 mg/m IV
(Day 1) , followed by fluorouracil
75 2
mg/m 2 1000 mg/m per day as a 24-hr IV
infusion (Days 1 to 4), starting at end
of cisplatin infusion; for 3 cycles.
Dosage adjustments recommendations
Liver dysfunction
AST/ALT >2.5 to ≤5 x ULN and AP ≤2.5 x ULN, or
AST/ALT >1.5 to ≤5 x ULN and AP >2.5 to ≤5 x ULN
Eutaxer Injection should be reduced by 20%.
AST/ALT >5 x ULN and/or AP >5 x ULN
Eutaxer Injection should be stopped.
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