Page 27 - Hikma - Oncology booklet
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Dosage cont.



        Induction therapy of locally advanced inoperable SCCHN
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                                             Followed by cisplatin 75 mg/m IV
                                                                                               2
                                             (Day 1) , followed by fluorouracil 750
                                 75                   2
                              mg/m    2      mg/m per day as a 24-hr IV infusion
                                             (Days 1 to 5), starting at end of

                                             cisplatin infusion; for 4 cycles.



        Induction therapy for locally advanced (unresectable, low

        surgical cure, or organ preservation) SCCHN:



                                                                                             2
                                             Followed by cisplatin 100 mg/m IV
                                             (Day 1) , followed by fluorouracil
                                 75                            2
                              mg/m    2      1000 mg/m per day as a 24-hr IV
                                             infusion (Days 1 to 4), starting at end

                                             of cisplatin infusion; for 3 cycles.



                       Dosage adjustments recommendations




        Liver dysfunction


                            AST/ALT >2.5 to ≤5 x ULN and AP ≤2.5 x ULN, or

                            AST/ALT >1.5 to ≤5 x ULN and AP >2.5 to ≤5 x ULN





                             Eutaxer Injection should be reduced by 20%.





                             AST/ALT >5 x ULN and/or AP >5 x ULN






                               Eutaxer Injection should be stopped.
          18/01/2020                                                                               3
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