Page 64 - Hikma - Oncology booklet

Dosage adjustments recommendations

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Withhold :

 Angina, MI, ischemia, arrhythmia, or HF.

 Hyperammonemic encephalopathy.

 Confusion, disorientation, ataxia

 Grade 3 or 4 diarrhea & mucositis.

 Grade 2 or 3 hand-foot syndrome.

 Grade 4 myelosuppression.

2 Administration at a  dose

Grade 1 diarrhea, mucositis, hand-foot

syndrome and myelosuppression.

Side effects

Hyperammonemic encephalopathy

Neurologic toxicity Cardiotoxicity

Mucositis Diarrhea

Myelosuppression Bronchospasm

Palmar-plantar erythrodysesthesia (hand-foot syndrome)
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