Page 60 - Hikma - Oncology booklet
P. 60

Drug interactions cont.



                                        Probenecid: May  Unitrexate exposure.
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                                        Consider alternative drugs.


                                        Theophylline: May  theophylline clearance.

                                        Monitor theophylline levels.

                        Side effects





             Ulcerative                                                        Fever, malaise

             stomatitis                                                          and fatigue

              Nausea &                                                           Chills and

       abdominal distress                                                        dizziness


          liver function                                                       Pulmonary

                 tests                                                            toxicity


                                                                             Hepatic & Renal
            Leukopenia
                                                                                    toxicity


                       Storage precaution





                                    Store refrigerated 2-8°C (36-46°F). After

                                    dispensing, store at room temperature
                                    15-30°C (59-86°F) for 60 days.



                       Pregnancy & Lactation





          Pregnancy                             Contraindicated






           Lactation                            Contraindicated
          18/01/2020                                                                               2
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