Page 68 - Hikma - Oncology booklet

Dosage adjustments recommendations

Peripheral Neuropathy
Click to edit Master title style

Grade 3 or persistent Grade 2 :

Interrupt Vinracine

Liver Functions

Serum bilirubin ≥ 3 mg/100 mL :

Reduce dose by 50%

Side effects

Edema, hyper and
Cardiovascular 01
hypotension, MI, CHD.

Coma, paralysis, neuralgia,
02 CNS
dizziness,  tendon reflex.

Dermatological 03 Alopecia and skin rashes.

Hyperuricemia, weight loss, Endocrine and
04
or uric acid nephropathy. metabolic

cramps, constipation,
GIT system 05
nausea, vomiting.

Bladder dysfunction,

urinary retention, dysuria. 06 Genitourinary
18/01/2020 2
67