Page 36 - Hikma - Oncology booklet

Dosage

Dose for Colorectal Cancer:
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200 by slow IV injection
mg/m 2
(minimum 3 minutes)

Followed by 5-fluorouracil , once a day for 5 days

Dose for Methotrexate Rescue, Methotrexate Overdosage:

 Nyrin rescue

IV, or IM, every 6
10
mg/m 2 hours for 10 doses

Start 24 hours after beginning of methotrexate infusion

2
(Based on a methotrexate dose of 12 to 15 g/m IV over 4 hours)

 Impaired Methotrexate Elimination or Inadvertent Overdosage:

IV, or IM, every 6 hours
10
mg/m 2 until methotrexate level is
-8
less than 10 mol

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