Page 18 - Hikma - Oncology booklet
P. 18
Dosage Con.
Myelodysplastic Disease , Myeloproliferative Disorder
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400 Orally once a day
mg
Systemic Mastocytosis
400
mg Orally daily
Renal Dose Adjustments
Mild renal impairment (CrCl 40 to 59 mL/min)
1 Doses >600 mg are not recommended
Moderate renal impairment (CrCl 20 to 39 mL/min)
2 Reduce starting dose by 50%
Severe renal impairment (CrCl less than 20 mL/min)
3
Caution recommended. A dose of 100 mg/day
was tolerated in 2 patients in a clinical study.
Liver Dose Adjustments
Mild or moderate Severe hepatic
hepatic impairment impairment
No adjustment Reduce the
recommended dose by 25%.
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