Page 14 - Hikma - Oncology booklet

Dosage Con.

Combination Therapy with Cyclophosphamide
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✓In advanced ovarian cancer

Carbotinol 300 600 Cyclophosphamide
mg/m 2 mg/m 2

IV on day 1 every 4 weeks for 6 cycles

Should not be repeated until the neutrophil count is at

least 2,000 and the platelet count is at least 100,000.

Dose Adjustment Recommendations

Acc.to platelet and neutrophil count :

Platelets Neutrophils Adjusted Dose (From Prior Course)

>100,000 >2,000 125%
50-100,000 500-2,000 No Adjustment

<50,000 <500 75%

In Patients with Impaired Kidney Function:

Baseline Creatinine Clearance Recommended Dose on Day 1

41-59 mL/min 250 mg/m2

16-40 mL/min 200 mg/m2

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